Tf-ijmf140585 331..337

Objective: To evaluate the shortand long-term outcomes among very low birth weight (VLBW) preterm infants after histologic chorioamnionitis (HCA). Methods: We performed a retrospective analysis of 5849 single infants (birth weight51500 g) born at a gestational age between 22+ 0 and 33+ 6 weeks. Clinical data were obtained from the Neonatal Research Network Japan between 2003 and 2007. Multivariable logistic regression analyses were performed to assess the effect of HCA on shortand long-term outcome. Results: According to logistic regression analysis, HCA was associated with lower incidence of respiratory distress syndrome (odds ratio [OR]1⁄4 0.54; p50.001), increased chronic lung disease (OR1⁄4 1.68; p50.001) and sepsis (OR1⁄4 1.71; p50.001) and as a short-term outcomes. There was no significant association with intraventricular hemorrhage (OR1⁄4 1.11; p1⁄4 0.33), periventricular leukomalacia (OR1⁄4 1.07; p1⁄4 .070) and death before discharge (OR1⁄4 0.97; p1⁄4 0.084). HCA was associated with increased home oxygen therapy (OR1⁄4 3.09; p50.001), but not with cerebral palsy (CP; OR1⁄4 0.91; p1⁄4 0.63), develop quotient570 (OR1⁄4 1.27; p1⁄4 0.17), visual impairment (OR1⁄4 1.08; p1⁄4 0.77), severe hearing impairment (OR1⁄4 1.28; p1⁄4 0.62) and death (OR1⁄4 0.98; p1⁄4 0.91) before three years of age. Conclusions: In this retrospective population-based study in Japan, HCA was not a risk factor for death, neurodevelopmental impairment and CP in VLBW three-year-old preterm infants.